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Hi Kevin, I saw your message yesterday and I emailed the contact I have at Dizal. This was the exact response I received this morning (see below). Frustrating, I know! Dear Stefanie, We appreciate your follow-up. Right now, we are actively working to establish the necessary infrastructure and processes ...

Hello Thoracic Team, Do you hold RET inhibitors (given their off-target VEGFR1 and VEGFR3 inhibition) for patients requiring dental surgery with manipulation around the jaw bone or only if on concurrent antiresorptive therapy with bisphosphonates or denosumab? I am seeing a low risk of ONJ in the literature ...

Hello Ashtin, I completely agree that this is a tough side effect to manage.We have tried dexamethasone oral solution 0.1 mg/mL swish and spit mouthwash for refractory dysgeusia. We use the same SIG as for Dato-DXd and everolimus (swish 10 mL for 1-2 mins then spit; no food or drink x 1 hr after use; ...

Yes, on 8/19/25 we were given the following information from the individual whose contact information I am copying below. I apologize that it is likely not the response you wanted to hear (it certainly is not what we were hoping to hear): At the moment, the drug will not be available for another 3 months ...

Hi Thoracic Colleagues! We have started a few patients on taletrectinib recently and have been monitoring uric acid per the PI. I looked at the protocol for the TRUST trials and could not find much guidance as to when you would consider initiating urate-lowering therapy. CTCAE grading of hyperuricemia ...