Hello Thoracic Team,
Do you hold RET inhibitors (given their off-target VEGFR1 and VEGFR3 inhibition) for patients requiring dental surgery with manipulation around the jaw bone or only if on concurrent antiresorptive therapy with bisphosphonates or denosumab?
I am seeing a low risk of ONJ in the literature from VEGF inhibition alone (< 1%) so thinking it may be okay to proceed as long as the procedure is not an extraction but looking for any additional experience or insight before I reply to my patient.
Thanks!
Stefanie Houseknecht, PharmD, BCOP
Clinical Pharmacy Specialist, Thoracic Malignancies
Johns Hopkins Hospital and Bayview Medical Center
ph: 443-401-3258