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Kate, We recently had a patient with both EGFR L858R and EGFR Exon 18 E709. She progressed on Osimertinib monotherapy after just under 2 years. We also debated next steps for her and ended up going with afatinib monotherapy based on https://pubmed.ncbi.nlm.nih.gov/38578683/ and other articles suggesting ...

As a follow up, the medications worked quickly, and her TG resulted at 485 one week later! She never developed any symptoms of pancreatitis.

Has anyone seen/treated a case of immunotherapy induced hypertriglyceridemia? This week a patient presented for her 10th total Pembrolizumab dose and brought a concerning lipid panel to clinic that was obtained less than 2 weeks ago (TG 872, total cholesterol >650). We repeated the panel fasted lipid ...