Thoracic Oncology

  • 1.  BiTE (tarlatamab) dysgeusia

    Posted 09-30-2025 11:36 AM

    I was wondering if anyone has had any luck with managing dysgeusia from tarlatamab or other bite therapies? We are seeing great responses from a cancer standpoint but patients are dropping significant amounts of weight from this adverse effect. It also doesn't appear to improve with duration of treatment. We have a patient that has been treating with tarlatamab for 14+ months and she still is dealing with this dysgeusia. Any helpful tips or tricks that have worked for you would be greatly appreciated. 



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    Ashtin Taylor
    Clinical Pharmacy Specialist - Thoracic and Sarcoma Malignancies
    Stephenson Cancer Center
    Oklahoma City OK

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  • 2.  RE: BiTE (tarlatamab) dysgeusia

    Posted 10-01-2025 07:19 AM
    Hello Ashtin,

    I completely agree that this is a tough side effect to manage.
    We have tried dexamethasone oral solution 0.1 mg/mL swish and spit mouthwash for refractory dysgeusia. We use the same SIG as for Dato-DXd and everolimus (swish 10 mL for 1-2 mins then spit; no food or drink x 1 hr after use; 4x/day).
    Dexamethasone oral solution is currently on shortage so may be challenging to find.

    Stefanie Houseknecht, PharmD, BCOP
    Ambulatory Thoracic Malignancies
    Johns Hopkins Hospital and Bayview Medical Center
    Baltimore, MD



    Original Message


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