Topic Thread

Bevacizuamb infusion times

  • 1.  Bevacizuamb infusion times

    Posted 06-13-2018 02:23 PM
    I know there is some information out there regarding 10 minute infusion times with bevacizumab. Anyone doing faster infusion times than the 90/60/30 min as listed in PI?

    Jamie Craig, PharmD, BCOP
    Clinical Pharmacy Specialist
    McLeod Physician Associates
    Florence, SC

  • 2.  RE: Bevacizuamb infusion times

    Posted 06-14-2018 01:31 AM
    We only do a 30 minute infusion. We do not start patients on the 90/60 mins. No issues.

    Kirollos S. Hanna, PharmD, BCPS, BCOP
    Hematology/Oncology Clinical Pharmacist | Univ. of Minnesota Medical Center & Mayo Clinic
    Pharmacist | CVS Health
    President-Elect | Minnesota Society of Health-System Pharmacists (Southern Affiliate)

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  • 3.  RE: Bevacizuamb infusion times

    Posted 06-15-2018 08:12 AM

    Good Morning,

    At MGH, we have been administering bevacizumab at 0.5mg/kg/min for a very long time. Bev 5mg/kg is given over 10 min, 10mg/kg over 20 min and 15mg/kg is given over 30 minutes. Drug has been well-tolerated.




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  • 4.  RE: Bevacizuamb infusion times

    Posted 06-14-2018 08:26 AM

    We switched to the faster infusions a couple of months ago.  For all doses, the first infusion is 30 minutes.  For subsequent doses (unless otherwise requested) the infusion times are 10min (5mg and 7.5mg), 20min (10mg), 30min (15 mg). 

    We have not seen any problems with the more rapid infusions.  We have had a few patients request the longer infusions, but for the most part it has been well tolerated.  It would be interesting to see the patient satisfaction data on this change.


    On a separate note, we also do Rapid Rituximab infusions and will be starting Rapid Daratumumab infusions in the next few weeks.

    Kathryn Wheeler PharmD, BCOP, BCPS
    Oncology Pharmacist - Lead
    Mission Health Cancer Care
    Asheville, NC 28801

  • 5.  RE: Bevacizuamb infusion times

    Posted 06-14-2018 09:11 AM
    We infuse bevacizumab at 0.5 mg/kg/minute.  I have only seen 1 patient unable to tolerate the faster infusion in the 5+ years I've been here.  These references may be useful for anyone evaluating the faster infusion:

    Reidy et al. J Clin Oncol 2007;25:2691-2695
    Shah et al. Ann Oncol 2013;24:960-965

    Laura A. Tuttle, PharmD, BCOP
    Clinical Oncology Pharmacist
    Smilow Cancer Hospital Care Centers
    Yale-New Haven Hospital

  • 6.  RE: Bevacizuamb infusion times

    Posted 06-14-2018 11:51 AM

    We only use 30 min infusions exclusively. There was a publication on this in JCO several years ago from MSKCC. We switched immediately after that was published. No problems since.


    Dayna McCauley BCOP,PharmD
    Good Samaritan Hospital
    West Islip NY