At MGH, we have been administering bevacizumab at 0.5mg/kg/min for a very long time. Bev 5mg/kg is given over 10 min, 10mg/kg over 20 min and 15mg/kg is given over 30 minutes. Drug has been well-tolerated.
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We switched to the faster infusions a couple of months ago. For all doses, the first infusion is 30 minutes. For subsequent doses (unless otherwise requested) the infusion times are 10min (5mg and 7.5mg), 20min (10mg), 30min (15 mg).
We have not seen any problems with the more rapid infusions. We have had a few patients request the longer infusions, but for the most part it has been well tolerated. It would be interesting to see the patient satisfaction data on this change.
On a separate note, we also do Rapid Rituximab infusions and will be starting Rapid Daratumumab infusions in the next few weeks.
We only use 30 min infusions exclusively. There was a publication on this in JCO several years ago from MSKCC. We switched immediately after that was published. No problems since.Dayna