Topic Thread

Pharmacokinetics of factor replacement therapy in hemophilia

  • 1.  Pharmacokinetics of factor replacement therapy in hemophilia

    Posted 6 days ago

    God afternoon

    I was wondering if anyone is doing individual Pharmacokinetics of factor replacement therapy in hemophilia patients. 


    Dr. Sameh Awwad, Pharm D. RPH. BCNSP

     Clinical Pharmacist

    Pediatric Oncology

  • 2.  RE: Pharmacokinetics of factor replacement therapy in hemophilia

    Posted 5 days ago
    Dr. Awwad,

    Yes, we offer PK analysis for individuals seen at our HTC. I have created an excel spreadsheet complete with computations which streamlines the process. Feel free to email to set up a time to chat if you would like to discuss further.

    Warm regards,

    Jeffrey Gilreath, PharmD
    Clinical Associate Professor
    Huntsman Cancer Institute - University of Utah
    Salt Lake City, UT 84112
    O: 801.587.5579

  • 3.  RE: Pharmacokinetics of factor replacement therapy in hemophilia

    Posted 4 days ago
    I strongly encourage your center participate in the WAPPS center, which uses population pharmacokinetic (popPK) models to personalize factor replacement therapy in hemophilia.  Not only are their dose adjustments more precise, but they are also taking an open team science approach to more rapidly help our hemophilia patients.  I hope that we embrace popPK models for drug dosing of our heme and oncology patients, since there are a multitude of examples showing the benefit of these models.

    Their website is here:  WAPPS-Hemo.  Here is their website's preamble.

    WAPPS Preamble:

    Welcome to the WAPPS-Hemo service's webpage. The WAPPS-Hemo project is a centralized, dedicated, web-accessible, actively moderated database that allows participating hemophilia centres to securely input factor VIII/IX plasma levels from sparse samples of their patients, returning individual pharmacokinetic estimates (PK). These estimates are generated by a proprietary automated population PK engine and manually validated.

    The specific aims of the service are:

    • to empower hemophilia treatment by facilitating individual PK assessment,
    • to allow for the robust estimation of individual PK parameters from a reduced number of plasma samples, and
    • to enhance knowledge about the value and application of population PK methodology to hemophilia care.

    You can find a few power point presentations about WAPPS here.

    If you wish to join this project, or just learn more about it, please contact us.

    Best Regards,
    The WAPPS-Hemo Project

    Jeannine McCune PharmD, BCOP
    Professor, Beckman Research Institute at the City of Hope
    Department of Population Sciences and Hematology and HCT
    Duarte CA